That is what the Scriptures mean when they say, ‘No eye has seen, no ear has heard, and no mind has imagined what God
Paul has been comparing human wisdom with God's wisdom in the previous verses. Human wisdom is based on what can be observed by the human senses and worked out from human logic and reason.
It was highly valued by the intellectuals of Paul's day. Reason and knowledge are applauded in the Bible, but not given the same lofty status as they are in an ungodly world (Proverbs 1:5; Colossians 2:8).
The problem with human wisdom is that it has no way of accessing God's wisdom. God's wisdom must be revealed and then believed or else it remains secret and hidden (Isaiah 55:8–9).
God established His wisdom before time began. It always included His plan to sacrifice His own Son to pay for human sin and make it possible for those who believe to share in His glory forever.
The rulers of this age could never have known that.